Acetylcholine synthesis in synaptosomes: mode of transfer of mitochondrial acetyl coenzyme A.

@article{Benjamin1981AcetylcholineSI,
  title={Acetylcholine synthesis in synaptosomes: mode of transfer of mitochondrial acetyl coenzyme A.},
  author={Abraham Moses Benjamin and J. H. Quastel},
  journal={Science},
  year={1981},
  volume={213 4515},
  pages={
          1495-7
        }
}
Labeled acetylcholine derived from labeled pyruvate in a synaptosomal preparation from rat brain, incubated with nicotinamide adenine dinucleotide as well as coenzyme A, is stimulated by calcium ions in the absence but not in the presence of Triton X-100. Whereas citrate is taken up by cholinergic synaptosomes because it suppresses the formation of acetylcholine from pyruvate, it is not itself converted into acetylcholine. The evidence suggests that there is a calcium-dependent transfer of… CONTINUE READING
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