Acetylcholine synthesis and accumulation in the CNS of Drosophila larvae: analysis of shibirets, a mutant with a temperature-sensitive block in synaptic transmission.

@article{Wu1983AcetylcholineSA,
  title={Acetylcholine synthesis and accumulation in the CNS of Drosophila larvae: analysis of shibirets, a mutant with a temperature-sensitive block in synaptic transmission.},
  author={C. F. J. Wu and J M Berneking and David L. Barker},
  journal={Journal of neurochemistry},
  year={1983},
  volume={40 5},
  pages={1386-96}
}
A radiochemical method is applied to the study of neurotransmitter metabolism in Drosophila. The larval CNS is a favorable system for analyzing acetylcholine (ACh) metabolism, since the pool of [3H]ACh rapidly reaches a steady state with a high ratio of intracellular [3H]ACh to [3H]choline. A temperature-sensitive paralytic mutant, shibirets, shows reduced [3H]ACh accumulation at the restrictive temperature. This reduction is not the result of decreased synthesis of [3H]ACh, but rather an… CONTINUE READING

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