Acetylcholine released by endothelial cells facilitates flow‐mediated dilatation

@inproceedings{Wilson2016AcetylcholineRB,
  title={Acetylcholine released by endothelial cells facilitates flow‐mediated dilatation},
  author={Calum Wilson and Matthew D. Lee and John G. McCarron},
  booktitle={The Journal of physiology},
  year={2016}
}
KEY POINTS The endothelium plays a pivotal role in the vascular response to chemical and mechanical stimuli. The endothelium is exquisitely sensitive to ACh, although the physiological significance of ACh-induced activation of the endothelium is unknown. In the present study, we investigated the mechanisms of flow-mediated endothelial calcium signalling. Our data establish that flow-mediated endothelial calcium responses arise from the autocrine action of non-neuronal ACh released by the… CONTINUE READING