Acetylcholine release in myasthenia gravis: regulation at single end-plate level.

@article{Plomp1995AcetylcholineRI,
  title={Acetylcholine release in myasthenia gravis: regulation at single end-plate level.},
  author={Jaap J. Plomp and Gertrudis Th H van Kempen and Marc de Baets and Yvo M. F. Graus and Jan B M Kuks and Peter Molenaar},
  journal={Annals of neurology},
  year={1995},
  volume={37 5},
  pages={627-36}
}
In myasthenia gravis, loss of acetylcholine receptors at motor end-plates is induced by antireceptor autoantibodies. At end-plates in rats in which myasthenia gravis-like symptoms are induced by chronic treatment with alpha-bungarotoxin, acetylcholine release is increased. Within muscles from such rats there is a strong correlation between the increase of acetylcholine release at an end-plate and the loss of postsynaptic acetylcholine receptors, caused by the toxin. The question is whether… CONTINUE READING