Acetylcholine release in experimental autonomic neuropathy.


Autonomic neuropathy is a common complication of diabetes. In this study we evaluated autonomic neuropathy by determining somatostatin (S-14)-evoked acetylcholine (Ach) release from postsynaptic parasympathetic fibers in the atria of controls (C) and streptozotocin diabetic rats (STZ-D), with and without tetrodotoxin (TTX). The release induced by S-14 did not differ in C and STZ-D. TTX blocked S-14 induced Ach in C but failed in STZ-D. TTX resistance in STZ-D may be explained by variations of membrane potential in nerve fibers.

Cite this paper

@article{Uccioli1991AcetylcholineRI, title={Acetylcholine release in experimental autonomic neuropathy.}, author={Luigi Uccioli and Paola Magnani and Paolo Tilli and Patrizia Cotroneo and Andrea Manto and Luca Mancini and Giovanna Monticone and A. V. Greco and Guido Menzinger and Giovanni Ghirlanda}, journal={Functional neurology}, year={1991}, volume={6 3}, pages={231-3} }