Acetylcholine release from growth cones detected with patches of acetylcholine receptor-rich membranes

@article{Hume1983AcetylcholineRF,
  title={Acetylcholine release from growth cones detected with patches of acetylcholine receptor-rich membranes},
  author={Richard I. Hume and Lorna W Role and Gerald D. Fischbach},
  journal={Nature},
  year={1983},
  volume={305},
  pages={632-634}
}
Synaptic potentials can be evoked at nerve–muscle junctions in vitro within minutes after an exploring growth cone contacts a receptive myotube1–3. Functional transmission is also evident in vivo on the time scale of minutes after motor axons enter adjacent myotomes4,5. The ability to release acetylcholine (ACh) may be induced in motor nerve terminals after they contact receptive target cells. Alternatively, growth cones may be capable of releasing ACh before contact. To examine the development… CONTINUE READING

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