Acetylcholine receptors of the Drosophila brain: a 900 bp promoter fragment contains the essential information for specific expression of the ard gene in vivo.

@article{Hess1994AcetylcholineRO,
  title={Acetylcholine receptors of the Drosophila brain: a 900 bp promoter fragment contains the essential information for specific expression of the ard gene in vivo.},
  author={N. Douglas Hess and Brenda Merz and Eckart D. Gundelfinger},
  journal={FEBS letters},
  year={1994},
  volume={346 2-3},
  pages={
          135-40
        }
}
The ard gene encodes a beta-subunit of Drosophila nicotinic acetylcholine receptors specifically expressed in a subset of neurons. To identify the cis-regulatory region responsible for this cell-specific expression, various 5' fragments of the ard gene were fused to a lacZ reporter gene and introduced into the Drosophila genome. A DNA fragment spanning approximately 760 bp upstream and approximately 140 bp downstream of a cluster of putative transcription start sites produced a pattern of beta… CONTINUE READING