Acetylcholine receptor organization in membrane domains in muscle cells: evidence for rapsyn-independent and rapsyn-dependent mechanisms.

@article{Piguet2011AcetylcholineRO,
  title={Acetylcholine receptor organization in membrane domains in muscle cells: evidence for rapsyn-independent and rapsyn-dependent mechanisms.},
  author={Joachim Piguet and Christoph Schreiter and J Segura and Horst Vogel and Ruud Hovius},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 1},
  pages={363-9}
}
Nicotinic acetylcholine receptors (nAChR) in muscle fibers are densely packed in the postsynaptic region at the neuromuscular junction. Rapsyn plays a central role in directing and clustering nAChR during cellular differentiation and neuromuscular junction formation; however, it has not been demonstrated whether rapsyn is the only cause of receptor immobilization. Here, we used single-molecule tracking methods to investigate nAChR mobility in plasma membranes of myoblast cells during their… CONTINUE READING