Acetylcholine mediates a slow synaptic potential in hippocampal pyramidal cells.

  title={Acetylcholine mediates a slow synaptic potential in hippocampal pyramidal cells.},
  author={Alison E. Cole and Roger A Nicoll},
  volume={221 4617},
The hippocampal slice preparation was used to study the role of acetylcholine as a synaptic transmitter. Bath-applied acetylcholine had three actions on pyramidal cells: (i) depolarization associated with increased input resistance, (ii) blockade of calcium-activated potassium responses, and (iii) blockade of accommodation of cell discharge. All these actions were reversed by the muscarinic antagonist atropine. Stimulation of sites in the slice known to contain cholinergic fibers mimicked all… CONTINUE READING
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