Corpus ID: 1121247

Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma.

@article{Song2003AcetylcholineIS,
  title={Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma.},
  author={P. Song and H. Sekhon and Y. Jia and J. A. Keller and J. Blusztajn and G. P. Mark and E. Spindel},
  journal={Cancer research},
  year={2003},
  volume={63 1},
  pages={
          214-21
        }
}
It is well established that small cell lung carcinomas (SCLCs) express receptors for acetylcholine (ACh) and that stimulation of these receptors by nicotine or other cholinergic agonists stimulates cell growth via activation of nicotinic cholinergic receptors (nAChRs) and/or muscarinic cholinergic receptors (mAChRs). The aim of this study was to determine whether SCLC cells synthesize and secrete ACh and respond to endogenous ACh to create a functioning cholinergic autocrine loop. Reverse… Expand
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References

SHOWING 1-10 OF 65 REFERENCES
Nicotine stimulates a serotonergic autocrine loop in human small-cell lung carcinoma.
Activation of M3 muscarinic acetylcholine receptors inhibits voltage-dependent calcium influx in small cell lung carcinoma.
α-Bungarotoxin blocks the nicotinic receptor mediated increase in cell number in a neuroendocrine cell line
Acetylcholine Receptors in Small Cell Carcinomas
Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines.
  • R. Maneckjee, J. Minna
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1990
Human placental cholinergic system.
  • B. Sastry
  • Biology, Medicine
  • Biochemical pharmacology
  • 1997
...
1
2
3
4
5
...