Acetylcholine induces neuritic outgrowth in rat primary olfactory bulb cultures

  title={Acetylcholine induces neuritic outgrowth in rat primary olfactory bulb cultures},
  author={Val{\'e}rie Coronas and Marielle Durand and J. G. Chabot and François Jourdan and Rémi Quirion},

Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb

It is suggested that activation of the cholinergic system promotes survival of newborn neurons in the adult dentate gyrus and olfactory bulb under both normal and stressed conditions.

Decreased neurogenesis after cholinergic forebrain lesion in the adult rat

It is proposed that the cholinergic system plays a survival‐promoting role for neuronal progenitors and immature neurons within regions of adult neurogenesis, similar to effects observed previously during brain development.

Cholinergic innervation of the zebrafish olfactory bulb

The presence of a functioning cholinergic system in the zebrafish OB is confirmed by observing a diffuse network of varicose ChAT‐positive fibers associated with the nervus terminalis ganglion innervating the mitral cell/glomerular layer (MC/GL).

Cholinergic differentiation of neural progenitors in adult mouse motor facial nucleus.

The results show that NPs, isolated from fetal mouse brain and transplanted into the non-neurogenic environment of the adult mouse facial nucleus, differentiate into cholinergic cells capable to project axons.

Acetylcholine influences growth cone motility and morphology of developing thalamic axons

In explant cultures, application of ACh reduced the length of thalamic axons in a dose dependent manner, an effect that could also be evoked by selective muscarinic and nicotinic agonists and in vitro assays found that ACh changed the morphology of growth cones; they became larger and extended more filopodia.

Activation of Alpha7 Subunit Containing Nicotinic Acetylcholine Receptors Mediates Cell Death of Neurons in the Avian Ciliary Ganglion

The results indicate that the control of cell death is more complex than originally proposed by the neurotrophic hypothesis and present the mechanism by which cell death in the developing ciliary ganglion is regulated, thus, further highlighting the importance of non-traditional roles of α7-nAChRs during the development of the nervous system.

Neurotransmitters as early signals for central nervous system development

It is argued that neurotransmitters could regulate morphogenetic events such as proliferation, growth, migration, differentiation and survival of neural precursor cells, and could lead to the development of pharmacological tools aimed at improving adult brain repair strategies.

Nicotinic Signaling in Development

This chapter will review recent findings indicating that endogenous nicotinic input is required for normal maturation of the nervous system and that excessive or altered Nicotinic signaling at early times can produce significant aberrations in the synaptic pathways that form.

Cholinergic impact on neuroplasticity drives muscarinic M1 receptor mediated differentiation into neurons

  • J. BenninghoffW. Rauh D. Rujescu
  • Biology
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2013
It is reported that muscarinic cholinergic neurotransmission stimulates differentiation of adult neural stem cells in vitro and appears to be predominantly mediated via the Muscarinic M1 receptor subtype.



Postnatal development of cholinergic markers in the rat olfactory bulb: A histochemical and immunocytochemical study

The development time course and distribution patterns of neuronal fibers and cell bodies displaying acetylcholinesterase (AChE) activity or choline acetyltransferase (ChAT) immunoreactivity in the rat olfactory bulb are defined and it is confirmed that the density of labelled fibers increases gradually in the postnatal period and spreads heterogeneously among the bulbar layers.

Cholinergic innervation of olfactory glomeruli in the rat: An ultrastructural immunocytochemical study

The ultrastructural organization of cholinergic afferents to the rat OBI was studied with the aid of choline acetyltransferase (ChAT) immunocytochemistry in electron microscopy to provide an anatomical substrate for the hypotheses concerning the complex effects of acetylcholine in the processing of sensory information in the olfactory bulb.

Postmitotic, postmigrational expression of tyrosine hydroxylase in olfactory bulb dopaminergic neurons

  • Jh McleanM. Shipley
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
The present results suggested that the input from the primary olfactory nerve is also necessary for the initial expression of the TOH phenotype, and suggest that specific cell-cell interactions play a key role in CNS neuronal transmitter phenotype regulation.

Developmental and aging aspects of the cholinergicinnervation of the olfactory bulb

Two anatomically specific classes of candidate cholinoceptive neurons in the rat olfactory bulb

  • W. NickellM. Shipley
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1988
The pharmacohistochemical technique of Butcher (1978) and choline acetyltransferase (ChAT) immunocytochemistry were used to demonstrate the presence, morphology, and differential distribution of 2

Nicotinic antagonists enhance process outgrowth by rat retinal ganglion cells in culture.

It is shown that within 24 hours of producing such a pharmacologic blockade, the retinal ganglion cells begin to sprout or regenerate neuronal processes, indicating the growth-enhancing effect of nicotinic antagonists may be due to the removal of inhibition to growth by tonic levels of ACh present in the culture medium.

Parallel Postnatal Development of Choline Acetyltransferase Activity and Muscarinic Acetylcholine Receptors in the Rat Olfactory Bulb

The parallel postnatal development of ChAT activity and muscarinic receptors suggests the existence of factors that couple the differentiation of presynaptic cholinergic terminals and postsynaptic cholinoceptive elements.

Synapse formation in the mouse olfactory bulb Quantitative studies

Volumetric synaptic density as well as absolute number of synapses per olfactory bulb for eight distinct synaptic types have been determined at 15 different ages, from the beginning of synapse formation at embryonic day 14 to postnatal day 44.

Neurotransmitters in the regulation of neuronal cytoarchitecture

  • M. Mattson
  • Biology, Psychology
    Brain Research Reviews
  • 1988