Acetylcholine-induced reversal of canine and feline atrial myocardial depression during stretch, cardiac failure, and drug toxicity.

@article{Gelband1975AcetylcholineinducedRO,
  title={Acetylcholine-induced reversal of canine and feline atrial myocardial depression during stretch, cardiac failure, and drug toxicity.},
  author={Henry Gelband and Robert Jerome Myerburg and Brian Francis Hoffman and Arthur L. Bassett},
  journal={Circulation research},
  year={1975},
  volume={37 5},
  pages={542-9}
}
Microelectrode and isometric recording techniques were used to evaluate the effects of acetycholine (ACh) on depressed isolated preparations of dog and cat atrial muscle. Atrial muscles were maintained at 36-37 degrees C with warmed Tyrode's solution and were stimulated at frequencies of 30 or 60/min. Depolarization to resting potentials of approximately… CONTINUE READING