Acetylcholine induced modulation of hippocampal pyramidal neurons.

  title={Acetylcholine induced modulation of hippocampal pyramidal neurons.},
  author={Larry S. Benardo and David A. Prince},
  journal={Brain research},
  volume={211 1},
Applications of acetylcholine to hippocampal slices maintained in vitro resulted in slow depolarizations and simultaneous increases in membrane resistance (RN)in hippocampal pyramidal neurons. Increases in RN had both voltage dependent and voltage independent components. These effects were associated with increases in cell discharge frequency, and development of spontaneous as well as synaptically and directly evoked burst discharges. The increase in RN and burst firing lasted for hours… CONTINUE READING