Acetylcholine-evoked calcium mobilization and ion channel activation in human labial gland acinar cells from patients with primary Sjögren's syndrome.

@article{Dawson2001AcetylcholineevokedCM,
  title={Acetylcholine-evoked calcium mobilization and ion channel activation in human labial gland acinar cells from patients with primary Sj{\"o}gren's syndrome.},
  author={Luke Dawson and Elizabeth Anne Field and Alexander R Harmer and Peter M Smith},
  journal={Clinical and experimental immunology},
  year={2001},
  volume={124 3},
  pages={480-5}
}
Recent evidence has indicated that the salivary gland dysfunction associated with Sjögren's syndrome (SjS) is not necessarily due to immune-mediated destruction of acinar tissue. SjS sufferers may possess substantial reserves of acinar tissue but nevertheless be incapable of maintaining salivary flow rates in the normal range. We have investigated the ability of isolated labial gland acinar cells from SjS patients to fluid secrete by measuring agonist-evoked changes in intracellular Ca(2+) ([Ca… CONTINUE READING