Acetylcholine causes endothelium-dependent contraction of mouse arteries.

  title={Acetylcholine causes endothelium-dependent contraction of mouse arteries.},
  author={Yingbi Zhou and Saradhadevi Varadharaj and Xue Ping Zhao and Narasimham L. Parinandi and Nicholas A Flavahan and Jay L. Zweier},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={289 3},
The goal of this study was to determine whether acetylcholine evokes endothelium-dependent contraction in mouse arteries and to define the mechanisms involved in regulating this response. Arterial rings isolated from wild-type (WT) and endothelial nitric oxide (NO) synthase knockout (eNOS(-/-)) mice were suspended for isometric tension recording. In abdominal aorta from WT mice contracted with phenylephrine, acetylcholine caused a relaxation that reversed at the concentration of 0.3-3 microM… CONTINUE READING
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