Acetylcholine and substance P stimulate bronchial epithelial cells to release eosinophil chemotactic activity.

@article{Koyama1998AcetylcholineAS,
  title={Acetylcholine and substance P stimulate bronchial epithelial cells to release eosinophil chemotactic activity.},
  author={Shinya Koyama and Eriko Sato and Hiromichi Nomura and Keishi Kubo and Shoya Nagai and Toru Izumi},
  journal={Journal of applied physiology},
  year={1998},
  volume={84 5},
  pages={1528-34}
}
We investigated a role of neuroregulation in the release of eosinophil chemotactic activity (ECA) from bovine bronchial epithelial cells (BBEC). BBEC were stimulated with acetylcholine (ACh) and substance P (SP), and the supernatant fluids were tested for ECA by a blind-well chemotactic chamber technique. BBEC released ECA in response to ACh and SP in a dose- and time-dependent manner. Checkerboard analysis showed that ECA in regard to ACh and SP was chemotactic rather than chemokinetic… CONTINUE READING
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Broncho-alveolar eosinophilia during allergen-induced late asthmatic reactions

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