Acetylcholine and norepinephrine mediate GABAergic but not glycinergic transmission enhancement by melittin in adult rat substantia gelatinosa neurons.

@article{Liu2011AcetylcholineAN,
  title={Acetylcholine and norepinephrine mediate GABAergic but not glycinergic transmission enhancement by melittin in adult rat substantia gelatinosa neurons.},
  author={Tao Liu and Tsugumi Fujita and Eiichi Kumamoto},
  journal={Journal of neurophysiology},
  year={2011},
  volume={106 1},
  pages={
          233-46
        }
}
GABAergic and glycinergic inhibitory synaptic transmissions in substantia gelatinosa (SG; lamina II of Rexed) neurons of the spinal dorsal horn play an important role in regulating nociceptive transmission from the periphery. It has not yet been well known whether each of the inhibitory transmissions plays a distinct role in the regulation. We report an involvement of neurotransmitters in GABAergic but not glycinergic transmission enhancement produced by the PLA(2) activator melittin, where the… 
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Anandamide Depresses Glycinergic and GABAergic Inhibitory Transmissions in Adult Rat Substantia Gelatinosa Neurons
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It is concluded that cannabinoids depress inhibitory transmissions in adult rat SG neurons by activating CB1 receptors in nerve terminals, which could contribute to the modulation of nociceptive transmission by cannabinoids.
Orexin B Modulates Spontaneous Excitatory and Inhibitory Transmission in Lamina II Neurons of Adult Rat Spinal Cord
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TLDR
Oxytocin produces a membrane depolarization mediated by oxytocin but not vasopressin-V1A receptors, which increases neuronal activity, resulting in the enhancement of inhibitory transmission, a possible mechanism for antinociception.
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TLDR
Cellular mechanisms for antinociceptive mechanisms among the hypothalamic neuropeptides and other endogenous pain modulators exhibiting a change in membrane potential, excitatory or inhibitory transmission in the spinal lamina II neurons are mentioned.
Actions of a novel water-soluble benzodiazepine-receptor agonist JM-1232(-) on synaptic transmission in adult rat spinal substantia gelatinosa neurons.
Presynaptic enhancement by eugenol of spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons is mediated by transient receptor potential A1 channels
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TLDR
The present findings reveal an important cellular link between neuronal and glial cells in the spinal dorsal horn and suggest that AMPA and NMDA receptors are positively modulated by IL-1β in a manner different from each other.
Functional expression and axonal transport of α7 nAChRs by peptidergic nociceptors of rat dorsal root ganglion
TLDR
Nerve crush experiments demonstrated that CGRPergic DRG nociceptors axonally transported α7 nAChRs both to the spinal cord and periphery, and it was found that nicotinic ligands affected neither their basal nor provoked levels, showing the necessity of further studies to elucidate the true role of α7nAChR in those neurons.
Regulation of nociceptive information transmitting to the spinal dorsal horn from periphery : the modulation of synaptic transmission and nerve conduction
TLDR
It is concluded that nociceptive transmission to the SG from periphery is regulated by modulating synaptic transmission and nerve conduction through an action of metabotropic neurotransmitter receptor and TRP agonists.
Noradrenaline modulates mechanically evoked responses in the rat spinal dorsal horn: an in vivo patch-clamp study
TLDR
The present data indicate that NA acts on noxious and innocuous mechanical transmission in the SG, which implies that NA exerts its analgesic effects in a manner more complicated than previously believed.
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