Acetylcholine and adenosine diphosphate cause endothelium-dependent relaxation of isolated human pulmonary arteries.

@article{Xuan1990AcetylcholineAA,
  title={Acetylcholine and adenosine diphosphate cause endothelium-dependent relaxation of isolated human pulmonary arteries.},
  author={A T Dinh Xuan and T. W. Higenbottam and Colin A Clelland and Joanna W Pepke-Zaba and Francis C. Wells and John Wallwork},
  journal={The European respiratory journal},
  year={1990},
  volume={3 6},
  pages={633-8}
}
Endothelium-dependent vasorelaxation mediated by endothelium-derived relaxing factors (EDRF) has been extensively studied in animals but only limited studies in man are available. Demonstration of EDRF-mediated dilatation of human vessels is fundamental for understanding the mechanisms of vascular diseases in man. We have investigated endothelium-dependent relaxation of isolated human pulmonary arteries. Vascular segments, taken from uninvolved regions of resected lung from eight patients… CONTINUE READING