Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes

@article{Ashkenazi1989AcetylcholineAS,
  title={Acetylcholine analogue stimulates DNA synthesis in brain-derived cells via specific muscarinic receptor subtypes},
  author={A. Ashkenazi and J. Ramachandran and D. Capon},
  journal={Nature},
  year={1989},
  volume={340},
  pages={146-150}
}
LITTLE is known about the factors which regulate the growth and development of the mammalian brain. Although proliferation of neuronal cells ceases relatively early in development, certain types of glial cells proliferate and differentiate mainly perinatally1. In the perinatal period, the ability of acetylcholine to stimulate phosphoinositide (PI) hydrolysis in brain reaches peak levels2, and indeed the stable acetylcholine analogue carbachol can stimulate PI hydrolysis of primary neonatal… Expand
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