Acetylcholine α7 nicotinic and dopamine D2 receptors are targeted to many of the same postsynaptic dendrites and astrocytes in the rodent prefrontal cortex.

@article{Duffy2011AcetylcholineN,
  title={Acetylcholine α7 nicotinic and dopamine D2 receptors are targeted to many of the same postsynaptic dendrites and astrocytes in the rodent prefrontal cortex.},
  author={{\'A}ine M. Duffy and Megan L Fitzgerald and June Shu-Ling Chan and Danielle C Robinson and Teresa A Milner and Kenneth Mackie and Virginia M Pickel},
  journal={Synapse},
  year={2011},
  volume={65 12},
  pages={
          1350-67
        }
}
The alpha-7 nicotinic acetylcholine receptor (α7nAChR) and the dopamine D(2) receptor (D(2) R) are both implicated in attentional processes and cognition, mediated in part through the prefrontal cortex (PFC). We examined the dual electron microscopic immunolabeling of α7nAChR and either D(2) R or the vesicular acetylcholine transporter (VAChT) in rodent PFC to assess convergent functional activation sites. Immunoreactivity (ir) for α7nAChR and/or D(2) R was seen in the same as well as separate… CONTINUE READING
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