Acetylcholine, aging, and Alzheimer's disease.

  title={Acetylcholine, aging, and Alzheimer's disease.},
  author={Janice L. Muir},
  journal={Pharmacology, biochemistry, and behavior},
  volume={56 4},
  • Janice L. Muir
  • Published 1997 in Pharmacology, biochemistry, and behavior
A substantial body of literature has suggested that the memory and learning deficits associated with Alzheimer's disease and aging are attributable to degeneration of the cholinergic magnocellular neurons of the nucleus basalis of Meynert (nbM). Subsequently, lesion-induced damage to the cholinergic projections from the nbM to the neocortex has been utilized extensively as an animal model of dementia. In addition, the effect of the normal aging process on deterioration of these neurons and on… CONTINUE READING