Acetylcarnitine, carnitine and glucose diminish the effect of muscarinic antagonist quinuclidinyl benzilate on striatal acetylcholine content.

@article{n1992AcetylcarnitineCA,
  title={Acetylcarnitine, carnitine and glucose diminish the effect of muscarinic antagonist quinuclidinyl benzilate on striatal acetylcholine content.},
  author={Jan Ř{\'i}{\vc}n{\'y} and Stanislav Tu{\vc}ek and Jana Nov{\'a}kov{\'a}},
  journal={Brain research},
  year={1992},
  volume={576 2},
  pages={215-9}
}
The content of acetylcholine (ACh) in the striatum, brain cortex and hippocampus of rats was lowered 20-180 min after intraperitoneal injection of the muscarinic antagonist quinuclidinyl benzilate (QNB). The depletion of ACh content in the striatum was diminished in animals treated with a single dose of acetyl-L-carnitine, L- or D,L-carnitine, or D-glucose. It is likely that QNB stimulates ACh release by blocking presynaptic muscarinic autoreceptors and that acetylcarnitine, carnitine and… CONTINUE READING