Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.

@article{Lin2013AcetylationSA,
  title={Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.},
  author={Ruiting Lin and Ren Tao and Xue Gao and Tingting Li and Xin Zhou and Kun Liang Guan and Yue Xiong and Qun-ying Lei},
  journal={Molecular cell},
  year={2013},
  volume={51 4},
  pages={506-518}
}
Increased fatty acid synthesis is required to meet the demand for membrane expansion of rapidly growing cells. ATP-citrate lyase (ACLY) is upregulated or activated in several types of cancer, and inhibition of ACLY arrests proliferation of cancer cells. Here we show that ACLY is acetylated at lysine residues 540, 546, and 554 (3K). Acetylation at these three lysine residues is stimulated by P300/calcium-binding protein (CBP)-associated factor (PCAF) acetyltransferase under high glucose and… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…