Acetylation regulates the stability of a bacterial protein: growth stage-dependent modification of RNase R.

@article{Liang2011AcetylationRT,
  title={Acetylation regulates the stability of a bacterial protein: growth stage-dependent modification of RNase R.},
  author={Wenxing Liang and Arun Malhotra and Murray P. Deutscher},
  journal={Molecular cell},
  year={2011},
  volume={44 1},
  pages={160-6}
}
RNase R, an Escherichia coli exoribonuclease important for degradation of structured RNAs, increases 3- to 10-fold under certain stress conditions, due to an increased half-life for this usually unstable protein. Components of the trans-translation machinery, tmRNA, and its associated protein, SmpB, are essential for RNase R instability. However, it is not understood why exponential phase RNase R is unstable or how it becomes stabilized in stationary phase. Here, we show that these phenomena… CONTINUE READING
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