Acetylation of trehalose mycolates is required for efficient MmpL-mediated membrane transport in Corynebacterineae.

@article{YamaryoBotte2015AcetylationOT,
  title={Acetylation of trehalose mycolates is required for efficient MmpL-mediated membrane transport in Corynebacterineae.},
  author={Yoshiki Yamaryo-Botte and Arek K Rainczuk and David J Lea-Smith and Rajini Brammananth and Phillip L. van der Peet and Peter J. Meikle and Julie E. Ralton and Thusita W T Rupasinghe and Spencer J Williams and Ross L Coppel and Paul K. Crellin and Malcolm J. McConville},
  journal={ACS chemical biology},
  year={2015},
  volume={10 3},
  pages={734-46}
}
Pathogenic species of Mycobacteria and Corynebacteria, including Mycobacterium tuberculosis and Corynebacterium diphtheriae, synthesize complex cell walls that are rich in very long-chain mycolic acids. These fatty acids are synthesized on the inner leaflet of the cell membrane and are subsequently transported to the periplasmic space as trehalose… CONTINUE READING