Acetylation of sox2 induces its nuclear export in embryonic stem cells.

@article{Baltus2009AcetylationOS,
  title={Acetylation of sox2 induces its nuclear export in embryonic stem cells.},
  author={Gretchen A. Baltus and Michael P. Kowalski and Huili Zhai and Antonin V. Tutter and Douglas M Quinn and Daniel Wall and Shilpa Kadam},
  journal={Stem cells},
  year={2009},
  volume={27 9},
  pages={
          2175-84
        }
}
Embryonic stem (ES) cells require a coordinated network of transcription factors to maintain pluripotency or trigger lineage specific differentiation. Central to these processes are the proteins Oct4, Nanog, and Sox2. Although the transcriptional targets of these factors have been extensively studied, very little is known about how the proteins themselves are regulated, especially at the post-translational level. Post-translational modifications are well documented to have broad effects on… CONTINUE READING
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