Acetylation of importin-α nuclear import factors by CBP/p300

  title={Acetylation of importin-α nuclear import factors by CBP/p300},
  author={Andrew J. Bannister and Eric A Miska and Dirk G{\"o}rlich and Tony Kouzarides},
  journal={Current Biology},
Histone acetylases were originally identified because of their ability to acetylate histone substrates [1–3]. Acetylases can also target other proteins such as transcription factors [4–7]. We asked whether the acetylase CREB-binding protein (CBP) could acetylate proteins not directly involved in transcription. A large panel of proteins, involved in a variety of cellular processes, were tested as substrates for recombinant CBP. This screen identified two proteins involved in nuclear import, Rch1… CONTINUE READING


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