Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei

@article{Siegel2008AcetylationOH,
  title={Acetylation of histone H4K4 is cell cycle regulated and mediated by HAT3 in Trypanosoma brucei},
  author={T Nicolai Siegel and Taemi Kawahara and Jeffrey A Degrasse and Christian J. Janzen and David Horn and George A. M. Cross},
  journal={Molecular Microbiology},
  year={2008},
  volume={67},
  pages={762 - 771}
}
Post-translational histone modifications have been studied intensively in several eukaryotes. It has been proposed that these modifications constitute a 'histone code' that specifies epigenetic information for transcription regulation. With a limited number of histone-modifying enzymes, implying less redundancy, Trypanosoma brucei represents an excellent system in which to investigate the function of individual histone modifications and histone-modifying enzymes. In this study, we characterized… CONTINUE READING