Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis.

@article{Bhattacharyya2009AcetylationOA,
  title={Acetylation of apurinic/apyrimidinic endonuclease-1 regulates Helicobacter pylori-mediated gastric epithelial cell apoptosis.},
  author={Asima Bhattacharyya and Ranajoy Chattopadhyay and Brent R Burnette and Janet V Cross and Sankar Mitra and Peter B. Ernst and Kishor K. Bhakat and Sheila Eileen Crowe},
  journal={Gastroenterology},
  year={2009},
  volume={136 7},
  pages={2258-69}
}
BACKGROUND & AIMS Helicobacter pylori-induced gastric epithelial cell (GEC) apoptosis is a complex process that includes activation of the tumor suppressor p53. p53-mediated apoptosis involves p53 activation, bax transcription, and cytochrome c release from mitochondria. Apurinic/apyrimidinic endonuclease-1 (APE-1) regulates transcriptional activity of p53, and H pylori induce APE-1 expression in human GECs. H pylori infection increases intracellular calcium ion concentration [Ca2+]i of GECs… CONTINUE READING

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