Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction

@article{Lu2011AcetylationOY,
  title={Acetylation of Yeast AMPK Controls Intrinsic Aging Independently of Caloric Restriction},
  author={Jin-ying Lu and Yu-Yi Lin and Jin-Chuan Sheu and June-Tai Wu and Fang-Jen S Lee and Yue Chen and Min-I Lin and Fu-Tien Chiang and Tong-Yuan Tai and Shelley L Berger and Yingming Zhao and K. -S. Tsai and Heng Zhu and Lee-Ming Chuang and Jef D. Boeke},
  journal={Cell},
  year={2011},
  volume={146},
  pages={969-979}
}
Acetylation of histone and nonhistone proteins is an important posttranslational modification affecting many cellular processes. Here, we report that NuA4 acetylation of Sip2, a regulatory β subunit of the Snf1 complex (yeast AMP-activated protein kinase), decreases as cells age. Sip2 acetylation, controlled by antagonizing NuA4 acetyltransferase and Rpd3 deacetylase, enhances interaction with Snf1, the catalytic subunit of Snf1 complex. Sip2-Snf1 interaction inhibits Snf1 activity, thus… CONTINUE READING

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