Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

  title={Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy},
  author={Sang-Won Min and Seo-Hyun Cho and Yungui Zhou and Sebastian Schroeder and Vahram Haroutunian and William W. Seeley and Eric H. Huang and Yong Shen and Eliezer Masliah and Chandrani Mukherjee and David M Meyers and Philip A Cole and Melanie Ott and Li Gan},
Neurodegenerative tauopathies characterized by hyperphosphorylated tau include frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) and Alzheimer's disease (AD). Reducing tau levels improves cognitive function in mouse models of AD and FTDP-17, but the mechanisms regulating the turnover of pathogenic tau are unknown. We found that tau is acetylated and that tau acetylation prevents degradation of phosphorylated tau (p-tau). We generated two antibodies specific for… CONTINUE READING
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Reisensburg Working Group for Tauopathies With Parkinsonism

  • A. C. Ludolph, J. Kassubek, +7 authors T Gasser
  • Eur. J. Neurol
  • 2009
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