Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment.

@article{Belman2015AcetylationOT,
  title={Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment.},
  author={Jonathan Belman and Rachel R Bian and Estifanos N. Habtemichael and Don T Li and Michael J Jurczak and Abel R. Alc{\'a}zar-Rom{\'a}n and Leah J. McNally and Gerald I Shulman and Jonathan S Bogan},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 7},
  pages={4447-63}
}
Insulin causes the exocytic translocation of GLUT4 glucose transporters to stimulate glucose uptake in fat and muscle. Previous results support a model in which TUG traps GLUT4 in intracellular, insulin-responsive vesicles termed GLUT4 storage vesicles (GSVs). Insulin triggers TUG cleavage to release the GSVs; GLUT4 then recycles through endosomes during ongoing insulin exposure. The TUG C terminus binds a GSV anchoring site comprising Golgin-160 and possibly other proteins. Here, we report… CONTINUE READING
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