Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.

@article{Schroeder2013AcetylationOR,
  title={Acetylation of RNA polymerase II regulates growth-factor-induced gene transcription in mammalian cells.},
  author={Sebastian Schroeder and Eva Herker and Friederike Itzen and Daniel He and Sean Thomas and Daniel A. Gilchrist and Katrin Kaehlcke and Sungyoo Cho and Katherine S. Pollard and John A. Capra and Martina Schnoelzer and Philip A Cole and Matthias Geyer and Benoit G Bruneau and Karen Adelman and Melanie Ott},
  journal={Molecular cell},
  year={2013},
  volume={52 3},
  pages={314-24}
}
Lysine acetylation regulates transcription by targeting histones and nonhistone proteins. Here we report that the central regulator of transcription, RNA polymerase II, is subject to acetylation in mammalian cells. Acetylation occurs at eight lysines within the C-terminal domain (CTD) of the largest polymerase subunit and is mediated by p300/KAT3B. CTD acetylation is specifically enriched downstream of the transcription start sites of polymerase-occupied genes genome-wide, indicating a role in… CONTINUE READING
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The code and beyond : transcription regulation by the RNA polymerase II carboxy-terminal domain

SPTSPT YSPTSP, YSPTSPS YSPTSPS YSPTSPS YSPTSPS YSPTSPS YSPTSPS YSPTSPS YS YSPTSP, +9 authors YSPT
2017

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