Acetylation of GATA-1 is required for chromatin occupancy.

  title={Acetylation of GATA-1 is required for chromatin occupancy.},
  author={Janine M. Lamonica and Christopher R Vakoc and Gerd A Blobel},
  volume={108 12},
All 3 hematopoietic GATA transcription factors, GATA-1, GATA-2, and GATA-3, are acetylated, although the in vivo role of this modification remains unclear. We examined the functions of an acetylation-defective mutant of GATA-1 in maturing erythroid cells. We found that removal of the acetylation sites in GATA-1 does not impair its nuclear localization, steady-state protein levels, or its ability to bind naked GATA elements in vitro. However, chromatin immunoprecipitation (ChIP) experiments… CONTINUE READING
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