Acetylation of Cytidine in mRNA Promotes Translation Efficiency

@article{Arango2018AcetylationOC,
  title={Acetylation of Cytidine in mRNA Promotes Translation Efficiency},
  author={Daniel Alejandro Echeverry Arango and David Sturgill and Najwa Alhusaini and Allissa A. Dillman and Shalini Oberdoerffer},
  journal={Cell},
  year={2018},
  volume={175},
  pages={1872-1886.e24}
}
Generation of the "epitranscriptome" through post-transcriptional ribonucleoside modification embeds a layer of regulatory complexity into RNA structure and function. Here, we describe N4-acetylcytidine (ac4C) as an mRNA modification that is catalyzed by the acetyltransferase NAT10. Transcriptome-wide mapping of ac4C revealed discretely acetylated regions that were enriched within coding sequences. Ablation of NAT10 reduced ac4C detection at the mapped mRNA sites and was globally associated… CONTINUE READING
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