Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.

@article{Li2012AcetylationMC,
  title={Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.},
  author={Tuo Li and Benjamin A. Diner and Jin Chen and Ileana M. Cristea},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 26},
  pages={10558-63}
}
Detection of pathogenic nucleic acids is essential for mammalian innate immunity. IFN-inducible protein IFI16 has emerged as a critical sensor for detecting pathogenic DNA, stimulating both type I IFN and proinflammatory responses. Despite being predominantly nuclear, IFI16 can unexpectedly sense pathogenic DNA in both the cytoplasm and the nucleus. However, the mechanisms regulating its localization and sensing ability remain uncharacterized. Here, we propose a two-signal model for IFI16… CONTINUE READING
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