Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population.

Abstract

BACKGROUND Epidemiologic studies have suggested that environmental factors and diet are important risk factors in the pathogenesis of prostate cancer. The N-acetyltransferases (NAT) are important enzymes in activation and inactivation of various carcinogens, including those found in well-cooked meat and cigarette smoke. METHODS We analyzed DNA samples from 146 prostate cancer patients and 174 healthy men. We used PCR-RFLP method to analyze NAT 1 and NAT 2 polymorphisms. RESULTS We did not find statistically significant differences in NAT 1 genotypes frequencies between prostate cancer patients and control group. We observed an association of the slow acetylator genotype, NAT 2*6/NAT2*6 with prostate cancer protection (P=0.017; OR=0.31, 95% CI 0.11--0.84). Multivariate logistic regression analysis confirmed this association (0.030; OR=0.32, 95% CI 0.12--0.89). CONCLUSIONS Our results indicate a role of NAT2 polymorphisms in the carcinogenic pathway of prostate cancer, specifically in a population of Southern Europe.

01020'06'07'08'09'10'11'12'13'14'15'16'17
Citations per Year

74 Citations

Semantic Scholar estimates that this publication has 74 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Costa2005AcetylationGA, title={Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population.}, author={Sandra Costa and Daniela Pinto and Antonio Higor Freire de Morais and Andr{\'e} Vasconcelos and Jorge M. A. Oliveira and Carlos Lopes and Rui Medeiros}, journal={The Prostate}, year={2005}, volume={64 3}, pages={246-52} }