Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population.


BACKGROUND Epidemiologic studies have suggested that environmental factors and diet are important risk factors in the pathogenesis of prostate cancer. The N-acetyltransferases (NAT) are important enzymes in activation and inactivation of various carcinogens, including those found in well-cooked meat and cigarette smoke. METHODS We analyzed DNA samples from 146 prostate cancer patients and 174 healthy men. We used PCR-RFLP method to analyze NAT 1 and NAT 2 polymorphisms. RESULTS We did not find statistically significant differences in NAT 1 genotypes frequencies between prostate cancer patients and control group. We observed an association of the slow acetylator genotype, NAT 2*6/NAT2*6 with prostate cancer protection (P=0.017; OR=0.31, 95% CI 0.11--0.84). Multivariate logistic regression analysis confirmed this association (0.030; OR=0.32, 95% CI 0.12--0.89). CONCLUSIONS Our results indicate a role of NAT2 polymorphisms in the carcinogenic pathway of prostate cancer, specifically in a population of Southern Europe.

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@article{Costa2005AcetylationGA, title={Acetylation genotype and the genetic susceptibility to prostate cancer in a southern European population.}, author={Sandra Costa and Daniela Pinto and Antonio Higor Freire de Morais and Andr{\'e} Vasconcelos and Jorge M. A. Oliveira and Carlos Lopes and Rui Medeiros}, journal={The Prostate}, year={2005}, volume={64 3}, pages={246-52} }