Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.

  title={Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.},
  author={Haijuan Wang and Michael P. Holloway and Li Ma and Zachary A Cooper and Matthew T Riolo and Ayman Samkari and Kojo S. J. Elenitoba-Johnson and Y Eugene Chin and Rachel A. Altura},
  journal={The Journal of biological chemistry},
  volume={285 46},
The multiple functions of the oncofetal protein survivin are dependent on its selective expression patterns within immunochemically distinct subcellular pools. The mechanism by which survivin localizes to these compartments, however, is only partly understood. Here we show that nuclear accumulation of survivin is promoted by CREB-binding protein (CBP)-dependent acetylation on lysine 129 (129K, Lys-129). We demonstrate a mechanism by which survivin acetylation at this position results in its… CONTINUE READING


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Survivin Acetylation Represses STAT3

C. D. Chung, J. Liao, +4 authors K. Shuai
J. Biol. Chem. 10.1074/jbc.M110.152777 • 1997

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