Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

  title={Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase},
  author={Virg{\'i}nia Guarani and Gianluca Deflorian and Claudio A. Franco and Marcus Krueger and Li-Kun Phng and Katie Bentley and Louise Toussaint and Franck Dequiedt and Ra{\'u}l Mostoslavsky and Mirko H H Schmidt and Barbara Zimmermann and Ralf Peter Brandes and Maria Caterina Mione and Christoph Westphal and Thomas Braun and Andreas Michael Zeiher and Holger Gerhardt and Stefanie Dimmeler and Michael Potente},
Notch signalling is a key intercellular communication mechanism that is essential for cell specification and tissue patterning, and which coordinates critical steps of blood vessel growth. Although subtle alterations in Notch activity suffice to elicit profound differences in endothelial behaviour and blood vessel formation, little is known about the regulation and adaptation of endothelial Notch responses. Here we report that the NAD+-dependent deacetylase SIRT1 acts as an intrinsic negative… CONTINUE READING
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