Acetylation curtails nucleosome binding, not stable nucleosome remodeling, by FoxO1.

Abstract

Transcriptional activity of FoxO factors is controlled through the actions of multiple growth factors signaling through protein kinase B, whereby phosphorylation of FoxO factors inhibits FoxO-mediated transactivation by promoting nuclear export. Phosphorylation of FoxO factors is enhanced by p300-mediated acetylation, which decreases their affinity for DNA… (More)
DOI: 10.1016/j.bbrc.2009.01.014

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