Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.

@article{Green2018AcetylationBE,
  title={Acetylation by Eis and Deacetylation by Rv1151c of Mycobacterium tuberculosis HupB: Biochemical and Structural Insight.},
  author={Keith D. Green and Tapan Biswas and Allan H. Pang and Melisa J. Willby and Matthew S. Reed and Olga Stuchlik and Jan Pohl and James E. Posey and Oleg V. Tsodikov and Sylvie Garneau‐Tsodikova},
  journal={Biochemistry},
  year={2018},
  volume={57 5},
  pages={
          781-790
        }
}
Bacterial nucleoid-associated proteins (NAPs) are critical to genome integrity and chromosome maintenance. Post-translational modifications of bacterial NAPs appear to function similarly to their better studied mammalian counterparts. The histone-like NAP HupB from Mycobacterium tuberculosis (Mtb) was previously observed to be acetylated by the acetyltransferase Eis, leading to genome reorganization. We report biochemical and structural aspects of acetylation of HupB by Eis. We also found that… Expand
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