Acetylation and alternative splicing regulate ZNF76-mediated transcription.

@article{Zheng2006AcetylationAA,
  title={Acetylation and alternative splicing regulate ZNF76-mediated transcription.},
  author={G. Zheng and Yu-Chung Yang},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={339 4},
  pages={
          1069-75
        }
}
  • G. Zheng, Yu-Chung Yang
  • Published 2006
  • Biology, Medicine
  • Biochemical and biophysical research communications
We previously showed that ZNF76 is a general transcription repressor targeting TATA-binding protein (TBP), through a process regulated by sumoylation [G. Zheng, Y.C. Yang, ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation, J. Biol. Chem. 279 (2004) 42410-42421]. In this study, two additional regulatory mechanisms for ZNF76 were identified. ZNF76 is acetylated by p300 and deacetylated by HDAC1, and acetylation of ZNF76 leads to its loss of… Expand
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