Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.

@article{Glozak2009AcetylationdeacetylationMT,
  title={Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.},
  author={Michele A. Glozak and Edward Seto},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 17},
  pages={11446-53}
}
Proper expression of the replication licensing factor Cdt1 is primarily regulated post-translationally by ubiquitylation and proteasome degradation. In a screen to identify novel non-histone targets of histone deacetylases (HDACs), we found Cdt1 as a binding partner for HDAC11. Cdt1 associates specifically and directly with HDAC11. We show that Cdt1 undergoes acetylation and is reversibly deacetylated by HDAC11. In vitro, Cdt1 can be acetylated at its N terminus by the lysine acetyltransferases… CONTINUE READING

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