Acetylated tubulin is essential for touch sensation in mice

@inproceedings{Morley2016AcetylatedTI,
  title={Acetylated tubulin is essential for touch sensation in mice},
  author={Shane J. Morley and Yanmei Qi and Loredana Iovino and Laura Andolfi and Da Wei Guo and Nereo Kalebic and Laura Castaldi and Christian Tischer and Carla Portulano and Giulia Bolasco and Kalyanee S Shirlekar and Claudia M Fusco and Antonino Asaro and Federica Fermani and Mayya Sundukova and Ulf Matti and Luc Reymond and Adele De Ninno and Luca Businaro and Kai Johnsson and Marco Lazzarino and Jonas Ries and Yannick Schwab and Jing Hu and Paul A Heppenstall},
  booktitle={eLife},
  year={2016}
}
At its most fundamental level, touch sensation requires the translation of mechanical energy into mechanosensitive ion channel opening, thereby generating electro-chemical signals. Our understanding of this process, especially how the cytoskeleton influences it, remains unknown. Here we demonstrate that mice lacking the α-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli. We show that all cutaneous afferent subtypes… CONTINUE READING

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