Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies.

@article{Irwin2012AcetylatedTA,
  title={Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies.},
  author={David J Irwin and Todd J Cohen and Murray Grossman and Steven E Arnold and Sharon X Xie and Virginia M-Y Lee and John Q. Trojanowski},
  journal={Brain : a journal of neurology},
  year={2012},
  volume={135 Pt 3},
  pages={
          807-18
        }
}
The microtubule-binding protein, tau, is the major component of neurofibrillary inclusions characteristic of Alzheimer's disease and related neurodegenerative tauopathies. When tau fibrillizes, it undergoes abnormal post-translational modifications resulting in decreased solubility and altered microtubule-stabilizing properties. Recently, we reported that the abnormal acetylation of tau at lysine residue 280 is a novel, pathological post-translational modification. Here, we performed detailed… CONTINUE READING

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