Acetylated microtubules are required for fusion of autophagosomes with lysosomes

@inproceedings{Xie2010AcetylatedMA,
  title={Acetylated microtubules are required for fusion of autophagosomes with lysosomes},
  author={Rui Dan Vicki Xie and Susan B. Nguyen and Wallace L. Mckeehan and Leyuan Liu},
  booktitle={BMC Cell Biology},
  year={2010}
}
Autophagy is a dynamic process during which isolation membranes package substrates to form autophagosomes that are fused with lysosomes to form autolysosomes for degradation. Although it is agreed that the LC3II-associated mature autophagosomes move along microtubular tracks, it is still in dispute if the conversion of LC3I to LC3II before autophagosomes are fully mature and subsequent fusion of mature autophagosomes with lysosomes require microtubules. We use biochemical markers of autophagy… CONTINUE READING
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LC3, a mammalian homologue

  • Y Kabeya, N Mizushima, +6 authors T Yoshimori
  • Xie et al. BMC Cell Biology
  • 2010
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