Acetylated histone H4 is reduced in human gastric adenomas and carcinomas.

  title={Acetylated histone H4 is reduced in human gastric adenomas and carcinomas.},
  author={Shinji Ono and Naohide Oue and Hiroki Kuniyasu and Tomoharu Suzuki and Reiko Ito and Keisuke Matsusaki and Tohru Ishikawa and Eiichi Tahara and Wataru Yasui},
  journal={Journal of experimental & clinical cancer research : CR},
  volume={21 3},
Acetylation of core histones is closely linked to transcriptional activation of various genes. The acetylation levels of nucleosomal histones can be modified through a balance of histone acetyltransferases and deacetylases. To elucidate the role of histone acetylation in human gastric carcinogenesis, we studied the status of histone H4 acetylation in gastric carcinoma tissues and corresponding non-neoplastic mucosa. The status of histone acetylation was assessed by examining the expression of… CONTINUE READING


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