Acetylamine derivative of diospyrin, a plant-derived binaphthylquinonoid, inhibits human colon cancer growth in Nod-Scid mice

@article{Hazra2014AcetylamineDO,
  title={Acetylamine derivative of diospyrin, a plant-derived binaphthylquinonoid, inhibits human colon cancer growth in Nod-Scid mice},
  author={Sudipta Hazra and Subhalakshmi Ghosh and Amit Kumar and B N Pandey and Banasri Hazra},
  journal={Investigational New Drugs},
  year={2014},
  volume={33},
  pages={22-31}
}
Anticancer activity of diospyrin and its derivatives (1–5) was evaluated against thirteen human cell lines. Compared to diospyrin (1), the acetylamine derivative (4) exhibited increase in cytotoxicity, particularly in HT-29 colon cancer cells, showing GI50 values of 33.90 and 1.96 μM, respectively. Also, enhanced toxicity was observed when cells, pre-treated with compound 4, were exposed to radiation. In vivo assessment of 4 was undertaken on tumour-bearing Nod-Scid mice treated at 4 mg/kg/day… CONTINUE READING
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