Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer.

@article{Wang2018AcetylmacrocalinBA,
  title={Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer.},
  author={Jing-nan Wang and Z R Zhang and Yun Che and Zu-Yang Yuan and Zhi-Liang Lu and Yuan Li and Ning Li and Jun Wan and Han-Dong Sun and Nan Sun and Pema-Tenzin Puno and Jie He},
  journal={Cancer biology & therapy},
  year={2018},
  volume={19 7},
  pages={
          609-621
        }
}
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, and novel effective drugs against NSCLC are urgently needed. Isodon species are rich in ent-kaurane diterpenoids that have been reported to have antitumor bioactivity. Acetyl-macrocalin B (A-macB) is a novel ent-kaurane diterpenoid isolated from Isodon silvatica, and… CONTINUE READING