Acetyl-l-carnitine protects striatal neurons against in vitro ischemia: The role of endogenous acetylcholine

@article{Picconi2006AcetyllcarnitinePS,
  title={Acetyl-l-carnitine protects striatal neurons against in vitro ischemia: The role of endogenous acetylcholine},
  author={Barbara Picconi and Ilaria Barone and Antonio Pisani and Raffaella Nicolai and Paolo Calabresi},
  journal={Neuropharmacology},
  year={2006},
  volume={50},
  pages={917-923}
}
The neuronal death after ischemia is closely linked to the essential role of mitochondrial metabolism. Inhibition of mitochondrial respiratory chain reduces ATP generation leading to a dysregulation of ion metabolism. Acetyl-L-carnitine (ALC) influences the maintenance of key mitochondrial proteins for maximum energy production and it may play a neuroprotective role in some pathological conditions. In this study we have analyzed ALC-mediated neuroprotection on an in vitro model of brain… CONTINUE READING

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